ABSTRACT
Despite vaccination, a substantial proportion of immunocompromised patients have an increased risk for severe Covid-19. Treatment with SARS-CoV-2 neutralizing monoclonal antibodies has been shown to be safe and can prevent Covid-19 associated hospitalization and death. Monoclonal antibodies neutralize the virus and promote the immune response against SARS-CoV-2. Treatment with monoclonal antibodies is a potential breakthrough for the treatment of patients who are at high risk for severe disease when given early after infection. The first encouraging clinical trial data and the imminent availability of combination antibody therapy create a "momentum" to address several essential questions that are necessary to address for the structural use of this treatment in routine clinical care. These concern the real-world effect and sustainability of treatment of vulnerable patients, the optimal logistics and the cost-effectiveness of these novel compounds.
ABSTRACT
Every day additional confirmed case of SARS-CoV-2 reinfection are being reported across the globe. In the Netherlands more than 50 cases of probable reinfections have been identified. With more than 500 thousand people in the Netherlands who have been infected with SARS-CoV-2 up till now this number does seems to be quite low. Still, important questions have to be asked. How do we define reinfection and how do these reinfections compare to other (corona) viruses? What is the immunological significance? What is the duration of protective immunity? And what does Covid-19 reinfections mean for the prevention and development of a vaccine? The described cases of re-infections do teach us that a SARS-CoV-2 vaccine should also be considered for people with a documented Covid-19 infection in the past and that general precautions, such as the use of face masks and social distancing, still apply to those with a previous SARS-CoV-2 infection.